He was one of the best con-men I have ever come across, he added. But it did not work, and a court in Sweden has found him criminally liable for the harm February 28, 2022 Emanuela Pecchia is famously known as the wife of popular Swiss-born Italian thoracic surgeon, Paolo Macchiarini. Benita Alexander thought that she was living a real-life fairy tale when she met her fianc, Paolo Macchiarini. Paolo was a world-renowned surgeon who spoke six languages, mingled with the global elite, and resembled George Clooney. Any woman would swoon for such a catch! Nevada Brazilian MMA fighters He is from Italy. In 2018, KI finally released the findings of its second investigation, which confirmed he had committed misconduct. This is how NBCs Meredith Vieira put it in her documentary about Macchiarini, appropriately called A Leap of Faith: Just imagine a world where any injured or diseased organ or body part you have is simply replaced by a new artificial one, literally manmade in the lab, just for you. This marvelous world was now within reach, thanks to Macchiarini. Paolo Macchiarini rode groundbreaking surgeries to global fame, but patients died anyway. Dressed in a white lab coat or in surgical scrubs, with his broad, handsome face and easy charm, he certainly looked the part. 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From November 2011 to June 2014, Paolo Macchiarini gave transplants to Christopher Lyles, Yulia Tuulik, Alexander Zozulya, Yesim Cetir, Hannah Warren (a 3-year-old), Sadiq Kanaan, and Dmitri Onogda. Macchiarini had often boasted to Alexander of his famous friends. She became close to Paolo as she opened her heart to him about how hard it was for her daughter, then nine years old, to lose her father. His net worth has been growing significantly in 2021-2022. No one wanted to collaborate with me. Alexander eventually fell in love with the surgeon, and in 2014, he proposed to her, and they started planning a lavish wedding for the following year. The Karolinska Institute was seduced by Macchiarini, said Dr. Gerdin. Talking about her spouse Paolo, he became infamous for research fraud and manipulative behavior. But, we now know that the success of this operation was a lie, and the complications she suffered because of it were kept under wraps for a really long time. Its kind of a marginal substitute, and many patients need further interventions to maintain their airways.. US Capitol Source: ABC Article continues below advertisement His relationship with Benita, In the first couple of years at Karolinska, he put plastic airways into three patients. He officially cleared Macchiarini of scientific misconduct, allowing merely that hed sometimes acted without due care. The popular press also has a lot to answer for. On May 13, Alexander left her job. That was a very smart idea to help maintain the fragile blood supply of the airway by leaving the esophagus in place behind it, Dr. Patterson said. ABCs true-crime documentary series The Con premieres with the story of Paolo Macchiarini, who was once considered a pioneer in the field of regenerative medicine but allegedly turned out to be just a fraud. The Karolinska Institute declined to comment for this article, noting only that Dr. Macchiarinis sentence may be appealed. It relieved a little bit of burden from him.. In January 2016, Macchiarini received an extraordinary double dose of bad press. But owing to her cancer returning and the formation of a fistula, she too passed away. So far he has not been prosecuted in any of those countries. The maximum prison sentence for causing bodily harm is 4 years. A few years ago, Japans Haruko Obokata pulled a similar con when she announced to the world a new and simple and fake method of turning ordinary body cells into stem cells. Thailand KI fired Macchiarini in March 2016, 2 months after the Swedish documentary came out. In 2016, Claudia returned to the Hospital Clinic to have her left lung removed, and as per the last reports, she is now alive and doing relatively well. Despite having a wife and a family, Paolo was in a public affair with the internet star Benita Alexandra. Its actually meaningless for him, Gerdin says. She received a new trachea in January and is believed to be the first patient in the world to undergo a successful direct transplant of a donor trachea.CreditSarah Blesener for The New York Times. Benita fell for Macchiarini while a producer for NBC, working on a story on him in 2013. The next morning, with the donor and Ms. Sein in adjacent rooms, a team of over 50 medical personnel assembled. By this year, Dr. Genden said, her condition had deteriorated so that if we delay further, its not going to work out.. The vice-chancellor, Anders Hamsten, resigned. How we can build a clean and renewable future. Hundreds of Americans are estimated to die each year because techniques like stents, surgery or lasers cannot heal their damaged tracheas, and they suffocate when airways narrow dangerously or collapse. In September, a Swedish prosecutor indicted him on aggravated assault charges related to three trachea transplants. Benita traveled to Paolo's Barcelona home with two friends and a video camera. But, he added, Its an indirect technique. It takes time and can replace only the tracheas halfpipe side, so its not a complete tube.. She pushed through his appointment despite the fact that he had some very negative references and dubious claims on his rsum. Macchiarini shot to prominence back in 2008, when he created a new airway for Claudia Castillo, a young woman from Barcelona. I Googled trachea transplant and Dr. Genden popped up. (LogOut/ In the case of Cetir, he should have known the risk of complications was higher than the expected benefit, the judges ruled. The couple had traveled extensively, but there were a Sonia Sein, outside her Bronx home, had irreparable damage to her trachea. Macchiarini gave his regenerating windpipes to 17 or more patients worldwide. What comes next after Texas school shooting? The donor was a young man (identifying details are being withheld to protect privacy). Paolo was in the house, but he was not alone after Benita's friends were asked to leave, they noticed a blonde woman coming out of the house, with two young children. If as a doctor you do stupid things, then you can be charged. But the not-guilty verdicts on the other two cases highlight how the law can leave vulnerable people unprotected, he says, for example when they are facing life-and-death decisions and holding less information than their doctor. Records show that even with his implant failing, Andemariam was able to complete his Ph.D. before his demise in January 2013. Team Lakay They didnt. All rights reserved. The trachea has been characterized as a simple tube, but its very complex, Dr. Delaere said. While there isnt enough data to actually prove this, we do have some key indicators. Does the heat of stem cell research the high levels of funding, prestige and media coverage it enjoys somehow encourage fraud? How climate change and forest management make wildfires harder to contain, Disparity in police response: Black Lives Matter protests and Capitol riot. At the trial, Macchiarini and his lawyer argued that the patients, with no other options, had been treated under compassionate care standards. Because immunosuppressant drugs are required to prevent rejection of the transplant, cancer patients would be eligible only if free of cancer for five years, Dr. Genden said. Guided by several mentors, he delved into research and animal experiments, developing a transplant approach. The procedure involved replacing a damaged trachea with a plastic replica that had been soaked in the patients stem cells. Most, including Andemariam Beyene, are now dead. The 18-hour procedure, conceived and led by Dr. Eric M. Genden Sr., chairman of otolaryngology-head and neck surgery at Mount Sinai Health System in New York, is a milestone because unlike kidneys, hearts and lungs the trachea has defied decades of transplantation attempts. Benita said that, if she can take any lessons away from what happened to her, she hopes that her experience will help others. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); This site uses Akismet to reduce spam. Euan Ward reported from London, and Christina Anderson from Bastad, Sweden. All but one died following severe complications with the implants. Photographs document Ms. Seins trachea transformation: Her old windpipe looks raw and red, her new one smooth as porcelain. The Karolinska University Hospital in Stockholm. Around the same time, an article in Vanity Fair described how Macchiarini had misled a girlfriendan NBC news producer working on a flattering documentary about his surgeriesinto thinking they would be married in a ceremony attended by the Clintons and Obamas and officiated by the pope. Learn how your comment data is processed. Even so, it wasnt until 2016 that the Karolinska Institute declined to renew his contract. Guided by a high-powered microscope, he used surgical thread half the diameter of a human hair. According to Pierre Delaere, a professor of respiratory surgery at KU Leuven, Belgium, Macchiarinis experiments were bound to end badly. Hes clearly bright and has accomplishments, but he cant contain himself. The Karolinska University Hospital suspended Dr. Macchiarinis contract as a surgeon in 2013, but the affiliated Karolinska Institute kept him on until 2016 even as the scandal over his work spread, according to a timeline on the institutes website. 2023 Warner Bros. New York Vanity Fair also later discovered that several of Paolo's other statements were false, including his claims about having been an associate professor at the University of Pisa. Still, noting that previous attempts didnt show documented success, he cautioned that longer-term results were needed before the technique should be embraced, adding, Lets see how it works and how you can do it in more patients.. Benita was also growing increasingly concerned, because she had not yet been introduced to Paolo's children or even seen where she was meant to live with him in Barcelona. Dr. Macchiarini received a conditional, or suspended, sentence, and was acquitted of assault charges related to two other patients who had also received the artificial organs from him at the Swedish facility. Benita told CrimeFeed that Paolo always paid for everything and was "extremely generous." The media began calling him "Dr. Frankenstein" and said that he committed "the world's biggest medical fraud.". Unfortunately, due to complications, she passed away either around Christmas of that year or in the first few months of 2009. And then there are the surgeons on Dr. Death. Likewise the whole idea of a wedding: Macchiarini was still married to his wife of 30 years. His recovery put Macchiarini on the front page of the New York Times. Benita Alexander on attending Paolo Macchiarinis criminal trial in Sweden Alexander said she attended Macchiarini's trial for closure, seven years after she was Look out for a message in your inbox in. But when Dr. Sander S. Florman, director of Mount Sinais Transplantation Institute, and LiveOnNY, a nonprofit organ donation organization, agreed to collaborate, his wife, Audrey, encouraged him. North Carolina Last year, however, the dream soured, exposing an ugly reality. I dont want to live like this, she concluded. Your tax-deductible contribution plays a critical role in sustaining this effort. Andemariam Beyene met up with Macchiarini in Iceland a year after his operation but later died Two more patients were also given transplants at the Karolinska In the Some answers have emerged from the official inquiries into the Karolinska Institute and the Karolinska University hospital. Benita first met Paolo at the bar at Bostons Mandarin Oriental hotel in February 2013, when she was helping coordinate an interview for an NBC special on regenerative medicine. California However, behind closed doors, Dr. Macchiarini was hiding a secret the procedures were not working. Benita packed her bags again, and began to search for Paolo in order to face him once more and their final confrontation is captured in He Lied About Everything. Texas Alexander admits that, at the time, she was in a vulnerable place. They should be. The Italian surgeon and his Italian wife Emanuela Pecchia have one son and one daughter. The only question was how long it would take weeks, months or a few years. Experts say this case is about what the definition of a resident is under Spanish law. He said yeah, so I said Lets go for it., After extracting the donors organs, you go next door and you open up Sonia and you remove the diseased trachea, and there is no going back, Dr. Genden said. And it needs a blood supply to connect to the patients vascular system. A version of this story appeared in Science, Vol 376, Issue 6600. But for now, lets focus solely on his medical patients, shall we? Today, Ms. Sein, 56, dances and plays tag with her grandchildren and plans to resume working, possibly as an acupuncturist. I didnt want the fairy tale to end., Alexander also hired a private investigator, a former Pennsylvania State Police detective named Frank Murphy. In 2015, the Karolinska Institute hired an independent investigator named Dr. Bengt Gerdin to look into the Macchiarini situation, per the Times. According to the Times, Macchiarini seen below in a 2017 interview on Swedens TV4 Nyheterna performed 20 tracheal regeneration procedures across Europe and in the United States but hid the fact that the transplants were failing. All three patients later died. (The big exception is blood stem cell transplantation, which has been saving the lives of people with leukemia and other cancers of the blood for decades.). Michigan Ground-breaking work on synthetic organ transplants made Paolo Macchiarini one of the most famous doctors in the world. In June 2016, the public prosecutor's office began investigating Paolo on suspicion of manslaughter and grievous bodily harm based on the material leading to the deaths of the three patients operated on in Sweden. Paolo Macchiarinis most notable patient is Claudia Castillo. Gerdin says the conviction on one count still shows that health care doesnt stand above the law. Thats something that was new to us, so we need to analyze that, Lundstrm-Kron says. Meanwhile, Macchiarinis career soared. Washington Macchiarini was also charged with but acquitted of assault charges related to the deaths of two more of his artificial windpipe patients, an Eritrean man named Andemariam Beyene and an American man named Christopher Lyles, according to BBC News. Back in New York, Benita found herself unable to stop thinking about Paolo's patients. At the time, Macchiarini was working at Swedens Karolinska Institute, which awards the Nobel Prize in Physiology or Medicine every year. About 11 centimeters (4 inches) long, one side curves like a halfpipe, composed of cartilage rings and ligaments. She soon went into full-on investigative journalist mode, and learned that Paolo had, yup lied about everything.